The National Research Ethics Board (NREB) was reconstituted in 2014, during the heat of the Ebola Virus Disease (EVD) Epidemics in Liberia, with the primary intent of protecting research participants whileaccounting for the interests of researcher during the implementation of research studies. The general ethical framework required for the Protection of research participants is based on the three pillars of respect for person (Autonomy), beneficence and justice. The NREB role is to principally analyze and assess the risk-benefit ratios of proposed research studies for the protection of research participants.